Cosimo Rosselli (1439–1507) was an Italian painter of the Quattrocento, active mainly in his birthplace of Florence, but also Lucca earlier in his career, and from 1480 in the Sistine Chapel in Rome, where he painted some of the large fresco panels on the side walls. Despite being roughly the same age (slightly older in each case) as Sandro Botticelli, Pietro Perugino and Domenico Ghirlandaio, the other leading Florentine painters, all regarded as greater talents, Rosselli was still able to win several large commissions, which is a testament to the high level of activity in the city.
He painted almost entirely religious subjects, with a few portraits. He did other large frescos with his workship, from which Fra Bartolomeo and Piero di Cosimo, who married Roselli's daughter, were his most famous pupils. These include a chapel in Sant'Ambrogio, Florence and one of the large spaces in the cloister of Santissima Annunziata, Florence.

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